89 ประโยชน์ของอาร์จินี (ProArgi 9 Plus) ที่คุณควรทาน เพราะจำเป็นต่อสุขภาพ
โดย : แฮร์รี่ Elwardt, ND, Ph.D.
รายงานต่อไปนี้ซึ่งได้รับการสนับสนุนโดยการวิจัยทางวิทยาศาสตร์ให้ผลที่น่าทึ่งแสดงให้เห็นถึงประโยชน์ของ Arginine มากมายต่อสุขภาพ Arginine ในร่างกายมนุษย์ เป็นกรดอะมิโนกึ่งจำเป็น ซึ่งผลิตได้ในตับและสามารถพบได้ในอาหารที่อุดมด้วยโปรตีนเช่นเนื้อแดง การวิจัยทางการแพทย์ได้แสดงให้เห็นว่าการเสริมด้วย Arginine 3 - 6 กรัม ต่อว่า สามารถให้ผลดีกับร่างการดังนี้
ริ้วรอย
•อาร์จินี ช่วยชลอการชรา (มันยับยั้งกระบวนการเสื่อมผิวพรรณ) (1)
• Arginine เพิ่มการกระตุ้นของฮอร์โมนการเจริญเติบโตของมนุษย์ (HGH) (ยังเป็นที่รู้จักกันเป็นฮอร์โมนต่อต้านริ้วรอย) จากต่อมใต้สมอง (2)
ระบบหัวใจและหลอดเลือด
• Arginine ช่วยเพิ่มการไหลเวียนของเลือดช่วยเพิ่มความสามารถในการออกกำลังกายและเพิ่มการขยายตัวของหลอดเลือดในผู้ป่วยโรคหลอดเลือดหัวใจตีบ (3)
•อาร์จินีจะช่วยป้องกันหลอดเลือดและลดความรุนแรงของความเสียหายของหลอดเลือด (4)
•อาร์จินียับยั้งการยึดเกาะของ ไขมันในผนังหลอดเลือด (5)
• Arginine ช่วยเพิ่มการไหลเวียนของเลือด (โดยกระตุ้นการผลิตไนตริกออกไซด์ซึ่งเป็นสารสื่อประสาทภายนอกที่ช่วยในการป้องกันไม่ให้ vasoconstriction และ
เริ่มต้นการขยายตัวของหลอดเลือดโดยการผ่อนคลายเซลล์กล้ามเนื้อเรียบของหลอดเลือด) (6)
•อาร์จินีจะช่วยป้องกันการแข็งตัวของเลือดผิดปกติ (โดยการกระตุ้นการผลิตของ plasmin และเพิ่มการขยายตัวของหลอดเลือดให้เพิ่มขึ้น) (7)
• Arginine ช่วยป้องกันไม่ให้เกิดความเสียหายจาการก่อตัวของอนุมูลอิสระที่เกิดขึ้นที่เยื่อบุของหลอดเลือด (โดยการเพิ่มการผลิตไนตริกออกไซด์ในหลอดเลือด) (8)
•อาร์จินีเพิ่มปริมาณจังหวะการเต้นของหัวใจและการส่งออก (ไม่มีผลกระทบต่ออัตราการเต้นของหัวใจ) ในผู้ป่วยหัวใจล้มเหลว นอกจากนี้ยังเพิ่มขยายตัวของหลอดเลือด
(ที่นำไปสู่การไหลเวียนของเลือดที่เพิ่มขึ้น) ในผู้ป่วยหัวใจล้มเหลวเหลว (9)
•อาร์จินีฟื้นฟูอาการของโรคหลอดเลือดหัวใจ(10)
•อาร์จินีลดความดันเลือดในผู้ป่วยความดันโลหิตสูงบางคน (โดยเพิ่มการผลิตไนตริกออกไซด์ (NO) และช่วยยับยั้งการ angiotensin แปลงเอนไซม์ (ACE)) (11)
•อาร์จินีฟื้นฟูอาการความดันโลหิตสูง (12)
•อาร์จินีลดความดันโลหิตสูง (13)
•อาร์จินีลดความดันโลหิตในปอดและช่วยเพิ่มการไหลเวียนของเลือดในผู้ป่วยความดันโลหิตสูงในปอด (14)
• Arginine เพิ่มระยะที่สามารถเดินในผู้ป่วยอัมพฤกษ์ (15)
•อาร์จินีคืนค่าฟังก์ชั่น endothelial ปกติไขมันในเลือดสูง (16)
• Arginine ช่วยเพิ่มระยะที่สามารถเดินในการเกิดโรคหลอดเลือด (17)
• Arginine ช่วยฟื้นฟูบาดแผลหลังการผ่าตัดบายพาส(18)
• Arginine ช่วยลดการอุดตันในหลอดเลือด(19)
• Arginine ช่วยป้องกัน restenosis หลังจาก angioplasty และบายพาส (20)
•อาร์จินีอาจให้การป้องกันอาการหัวใจวาย (21)
• Arginine ช่วยลดภาวะหัวใจล้มเหลว (22)
• Arginine ช่วยลดการเกิดโรคหลอดเลือด (23)
ระบบย่อยอาหาร
ขาด• Arginine สามารถทำให้เกิดอาการท้องผูก.
• Arginine เสริมอาจลดอุบัติการณ์ของโรคนิ่ว.
• Arginine ช่วยลดการซึมผ่านลำไส้ (เนื่องจากบทบาทของอาร์จินีในการผลิตไนตริกออกไซด์) (24)
•อาร์จินีบรรเทาหลายกรณีของลำไส้ใหญ่ (โดยการส่งเสริมการรักษาของแผลที่เกิดขึ้นในลำไส้ใหญ่ของผู้ป่วยลำไส้ใหญ่) ที่(25)
•อาร์จินีอาจฟื้นฟูอาการลำไส้แปรปรวน (IBS)(26)
• Arginine ช่วยลดแผล (27)
•อาร์จินีจะช่วยป้องกันการอักเสบหลังจากการผ่าตัดลำไส้(28)
• Arginine ช่วยเพิ่มผลใน sepis (29)
ระบบขับถ่าย
•อาร์จินีบรรเทาความเจ็บปวดและความรู้สึกไม่สบายที่เกี่ยวข้องกับโรคกระเพาะปัสสาวะอักเสบ (30)
•อาร์จินีช่วยฟื้นฟูการทำงานของไตและช่วยในการป้องกันการเสื่อมของไต (31)
ระบบภูมิคุ้มกัน
• Arginine ช่วยในการป้องกันโรคจากเชื้อแบคทีเรียและไวรัสในผู้ที่มีความเก็บกดภูมิคุ้มกันระบบ (32)
•Arginine บล็อคการก่อตัวของโรคมะเร็งบางชนิด (arginine ยับยั้งเซลล์มะเร็งในสัตว์ทดลอง 24 ชนิดที่แตกต่างของโรคมะเร็งในสัตว์) (33)
• Arginine ช่วยเพิ่มความสามารถของระบบภูมิคุ้มกันของร่างกายในการต่อสู้กับโรคมะเร็งเต้านม (34)
• Arginine ช่วยลดการสังเคราะห์โปรตีนเนื้องอกและอัตราการเจริญเติบโตของเนื้องอกในโรคมะเร็งตับ (35)
•อาร์จินียับยั้งการเจริญเติบโตของบางชนิดของมะเร็ง (36)
•หนึ่งในวิธีการที่อาร์จินีต่อต้านโรคมะเร็งโดยการลดกิจกรรมของ decarboxylase Ornithine เป็นเอนไซม์ที่เกี่ยวข้องกับโรคมะเร็งบางชนิด.
* ข้อควรระวัง: Arginine นอกจากนี้มีข้อสันนิษฐานถีงผลรุนแรงโรคมะเร็งบางชนิด แต่นี้คือ เพียงทฤษฎี.
• Arginine ช่วยเพิ่มผลของการรักษาโรคมะเร็ง(37)
•อาร์จินี (ในปริมาณที่ไม่มากเกินไป) ช่วยกระตุ้นการทำงานของระบบภูมิคุ้มกัน (38)
• Arginine ช่วยกระตุ้นการผลิต T-เซลล์(39)
•อาร์จินีช่วยกระตุ้นการทำงานและการผลิตเซลล์เม็ดเลือดขาวโดยต่อมไธมัส (40)
• Arginine เพิ่มการทำงาน ของเซลล์เม็ดเลือดขาว NK (41)
• Arginine ช่วยกระตุ้นการผลิตเซลล์เม็ดเลือดขาว T-ภายในต่อมไธมัสและทำให้ทำงานได้มากขึ้นและมีประสิทธิภาพ (42)
• Arginine เพิ่มขนาดของไธมัสที่ช่วยกระตุ้นการผลิตของเซลล์เม็ดเลือดขาวโดย ไธมัสและเรียกคืนการผลิตฮอร์โมน thymic ให้อยู่ในระดับอ่อนเยาว์ (43)
•อาร์จินีช่วยในการต่อต้านการอักเสบ (44)
•อาร์จินีเร่งการทำงานของระบบภูมิคุ้มกันของร่างกายในการฟื้นฟูจากการผ่าตัด (45)
• Arginine ช่วยเพิ่มเซลล์เคียว (46)
การเผาผลาญ
• alkalosis สามารถเกิดขึ้นเป็นผลมาจากการขาดอาร์จินี (47)
•อาร์จินีมีผลในการต้านอนุมูลอิสระและขับไล่อนุมูลอิสระ superoxide (48)
• Arginine ช่วยลดระดับคอเลสเตอรอลในเลือดทั้งหมด (49)
•อาร์จินีลดระดับไลโปโปรตีน (LDL) (50)
•อาร์จินี inibits กระบวนการของการข้ามการเชื่อมโยง (51)
• Arginine ช่วยลดความต้านทานต่ออินซูลินและช่วยเพิ่มการกำจัดน้ำตาลในเลือดในผู้ป่วยเบาหวานชนิด
ที่ 2 ผู้ป่วย (52)
• Arginine ช่วยลดความต้านทานต่ออินซูลิน (53)
• Arginine ช่วยลดอาการโรคเบาหวานและป้องกันความเสียหายที่เกิดจากโรคเบาหวาน (54)
•อาร์จินีช่วยป้องกันโรคเบาหวาน (55)
• Arginine เพิ่มการดูดซึมออกซิเจนในปอดในผู้ที่มีออกซิเจน (เนื่องจากบทบาทในการผลิตไนตริกออกไซด์ซึ่งช่วยเพิ่มการไหลเวียนของเลือดผ่าน vasodilation) (56)
• Arginine เพิ่มการดูดซึมออกซิเจนในปอด (เนื่องจากบทบาทของตัวเองในการผลิตไนตริกออกไซด์ซึ่งจะช่วยเพิ่มการไหลเวียนของเลือดผ่าน vasodilation) (57)
• Arginine ช่วยลดอาการโรคหอบหืด (58)
•อาร์จินีช่วยในการล้างพิษในตับและบรรเทาโรคตับแข็ง ความผิดปกติของตับสามารถเกิดขึ้น เป็นผลมาจากการขาดอาร์จินี (59)
• Arginine ช่วยลดระดับไตรกลีเซอไรด์สูง (60)
•อาร์จินีบรรเทาโรคอ้วนและช่วยในการลดน้ำหนัก (โดยการกระตุ้นหลั่งฮอร์โมนการเจริญเติบโตของมนุษย์ (HGH) จากต่อมใต้สมอง) (61)
ระบบกล้ามเนื้อ
• Arginine ฟื้นฟูการรักษาอาการกระดูกหัก (62)
•อาร์จินีช่วยเสริมสร้างการเจริญเติบโตของกล้ามเนื้อ (โดยการลดการสูญเสียมวลกล้ามเนื้อ) และเป็นสิ่งจำเป็นสำหรับ
การขนส่งของไนโตรเจนที่ใช้ในการเผาผลาญอาหารของกล้ามเนื้อ (63)
•กล้ามเนื้ออ่อนแรงสามารถเกิดขึ้นเป็นผลมาจากการขาดอาร์จินี (64)
•อาร์จินีอาจป้องกันและบรรเทาโรคกระดูกพรุน (โดยการกระตุ้นการหลั่งฮอร์โมนการเจริญเติบโต (HGH) ซึ่งเป็นส่วนสำคัญของการสร้างกระดูกและกระดูก และยังช่วยกระตุ้นการสังเคราะห์ไนตริกออกไซด์ซึ่งเป็นสารยับยั้งที่มีศักยภาพของ osteoclasts ที่ก่อให้เกิด การสลายของกระดูก)(65)
•เป็นสารตั้งต้นในการผลิตไนตริกออกไซด์ที่อาร์จินีทำให้เกิดการผ่อนคลายของกล้ามเนื้อ (66)
• Arginine ช่วยเพิ่มประสิทธิภาพการทำงานของกล้ามเนื้อ (67)
• Arginine ช่วยเพิ่มการดูดซึมกลูโคสเข้าสู่เซลล์กล้ามเนื้อ (68)
ระบบประสาท
•อาร์จินีอาจจะมีประโยชน์สำหรับการรักษาโรคอัลไซเม (เนื่องจากความสามารถในการซ่อมแซมความเสียหายซอนโดยการเพิ่มระดับโพลีเอไม) (69)
•อาร์จินีเป็นสิ่งจำเป็นสำหรับการฟื้นฟูผซ่อมแซมส่วนที่เสียหายของเซลล์ประสาท (70)
•อาร์จินีช่วยฟื้นฟูใน potentiation ของหน่วยความจำระยะยาว (โดยการกระตุ้นการผลิตไนตริกออกไซด์ (NO) - สารสื่อประสาทที่รับผิดชอบในการ potentiation (การเก็บรักษา) ของ หน่วยความจำระยะยาว (71)
• Arginine ช่วยเพิ่มหน่วยความจำและความรู้ความเข้าใจในการทำงานของระบบประสาท . (72)
• Arginine ช่วยเพิ่มการตอบสนองของต่อมใต้สมองและ modulates ควบคุมฮอร์โมน. (73)
เพศของระบบ
•อาร์จินีบรรเทาความหย่อนสมรรถภาพในผู้ชาย (โดยกระตุ้นการผลิตไนตริกออกไซด์ที่สารเคมีภายนอกที่ช่วยกระตุ้นการแข็งตัวในอวัยวะเพศชาย) (74)
•อาร์จินีบรรเทาภาวะมีบุตรยากในผู้ชายโดยการเพิ่มจำนวนอสุจิและการเคลื่อนไหวของอสุจิ (เนื่องจากการ
มีส่วนร่วมในการผลิตของสเปอร์ภายนอก) (75)
•อาร์จินี ช่วยกระตุ้นความต้องการทางเพศ (ชายและหญิง) (ความใคร่) (76)
•อาร์จินีช่วยเสริมสมรรถภาพทางเพศ (หญิง) - เนื่องจากบทบาทของตัวเองในการผลิตไนตริกออกไซด์ในอวัยวะเพศหญิง (ไนตริกออกไซด์ช่วยเสริมสร้างในการสำเร็จความใคร่หญิงในอวัยวะเพศหญิง) (77)
• Arginine ช่วยเพิ่มสมรรถภาพทางเพศ (ชาย) โดยการให้ไนโตรเจนไนตริกออกไซด์ (NO) โมเลกุลที่เป็นส่วนประกอบที่สำคัญในการช่วยการแข็งตัวของอวัยวะเพศชาย ให้มีขนาดใหญ่หนักและอึดทนแข็งตัวเป็นระยะเวลานานขึ้น (78)
• Arginine ช่วยเพิ่มจำนวนอสุจิและการเคลื่อนไหวของอสุจิ (79)
•อาร์จินีช่วยฟื้นฟูทำงานของต่อมลูกหมาก(80)
•อาร์จินีลดอาการฝ่อของลูกอัณฑะ
ผิว / ผม
• อาร์จีนินลดอาการสูญเสียเส้นผม (โดยเฉพาะเพศชายศีรษะล้าน) (81)
•อาร์จินีช่วยผิวพรรณเปล่งปลั่ง
•อาร์จินี (ใช้ topically) ช่วยเพิ่มการทำงานของเลือดฝอย ใต้ผิว (82)
• Arginine ช่วยกระตุ้นการขยายตัวของเซลล์ผิว (83)
•อาร์จินีเป็นสิ่งจำเป็นสำหรับและเร่งการรักษาบาดแผล (โดยการกระตุ้นการหลั่งฮอร์โมนการเจริญเติบโตของมนุษย์ (HGH) กระตุ้นการผลิตคอลลาเจนและกระตุ้นการงอกของเซลล์) ที่ (84)
•อาร์จินีเร่งการรักษาจากการเผาไหม้ (85)
•อาร์จินีช่วยฟื้นฟูสมานบาดแผลจากการผ่าตัด (86)
•อาร์จินีลดการติดเชื้อและลดระยะเวลาในการเข้าพักที่โรงพยาบาล (87)
• Arginine ช่วยเพิ่ม scleroderma (88)
ความปลอดภัย
•อาร์จินีได้รับการแสดงเพื่อความปลอดภัยในการศึกษาดังกล่าวข้างต้นเช่นเดียวกับพันของคนอื่น ๆ (89)
•อาร์จินีถูกนำมาใช้อย่างปลอดภัยในมนุษย์มากกว่า 30 ปี
Research
1. Radner, W., et al. L-arginine reduces kidney collagen accumulation and N-epsilon-(carboxymethyl)lysine in the aging NMRI-mouse. J Gerontol. 49(2):M44-M46, 1994.
2. Gianotti L, Macario M, Lanfranco F, et al. Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab 2000 Oct;85(10):3604-8.
3. Ceremuzynski, L., et al. Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris. Am J Cardiol. 80:331-333, 1997.
4. Adams, R. R., et al. Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis. 129(2):261-269, 1997.
5. Adams, M. R., et al. Cigarette smoking is associated with increased human monocyte adhesion to endothelial cells: reversibility with oral L-arginine but not vitamin C. Journal of the American College of Cardiology. 29(3):491-497, 1997.
6. Huk, I., et al. L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemica/reperfusion injury in skeletal muscle. Circulation. 96:667-675, 1997.
7. Drexler H, et al. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. The Lancet. 338:1546-50, 1991.
8. Huk, I., et al. L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemica/reperfusion injury in skeletal muscle. Circulation. 96:667-675, 1997.
9. Koifman, B., et al. Improvement of cardiac performance by intravenous infusion of l-arginine in patients with moderate congestive heart failure. Journal of the American College of Cardiology. 26(5):1251-6, 1995.
10. Quyyumi AA. Does acute improvement of endothelial dysfunction in coronary arterydisease improve myocardial ischemia? J Am Coll Cardiol 1998 Oct;32(4):904-11.
11. Khosh, F. Natural approach to hypertension. Alternative Medicine Review. 6(6), 2001.
12. Sisic D, Francishetti A, Frolich ED. Prolonged L-arginine on cardiovascular mass and myocardial hemodynamics and collagen in aged spontaneously hypertensive and normal rats. Hypertension 1999 Jan;33(1 Pt 2):451-5.
13. Nakaki T, et al. L-arginine induced hypotension. Lancet 1990Oct 20; 336(8721):1016-7.
14. Nagaya, N., et al. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Resp Crit Care Med. 163(4):887-891, 2001.
15. Roberts, A. J., et al. Nutraceuticals: The Complete Encyclopedia of Supplements, Herbs, Vitamins and Healing Foods. Berkely Publishing Group. New York, USA. 2001:319.
16. Maxwell AJ, Anderson B Zapien MP, Cooke JP. Endothelial dysfunction in hypercholesterolemia is reversed by: nutritional product designed to enhance nitric oxide activity. Cardiovasc Drugs Ther 2000 Jun;14(3):309-16.
17. Maxwell AJ, Anderson BE Cooke JP. Nutritional therapy for peripheral artery disease. Vasc Med 2000;5(1):11-19.
18. Wallace AW, Ratcliffe MB, Galindez D, Kong JS. L-arginine infusion dilates coronary vasculature in patients undergoing coronary bypass surgery Aenesthesiology 1999 Jun;90(6):1577-8.
This is third party information. This is for informational purposes only and is not intended to be used for marketing purposes.
19. Bode-Boger SM, Boger RH, et al. Differential inhibition of human platelet aggregation and thromboxane A 2 formation by L-arginine in vivo and in vitro. Arch Pharmacol 1998; 357:143-150.
20. Le Yorneau T, Van Belle E, Corseaux D, et al . Role of nitric oxide in re-stenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit. J Am CollCardiol 1999 Mar;33(3):876-82.
21. Suematsu Y, Ohtsuka T, et al. L-Arginine given after ischemic preconditioning can enhance cardioprotection in isolated rat hearts. Eur J Cardiothorac Surg 2001, Jun;19(6):873-9.
22. Hambrecht R, et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol 2000 Mar 1; 35(3):706-13.
23. Bode-Boger SM, Boger RH,et al. L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study. Circulation 1996 Jan 1; 93(1):85-90.
24. Miller, A. L. The pathogenesis, clinical implications, and treatment of intestinal hyperpermeability. Alternative Medicine Review. 2(5):330-345, 1997.
25. Segala, M. (editor). Disease Prevention and Treatment 3rd Edition. Life Extension Media. Florida, USA. 2000:202.
26. Sahin AS, Atalik KE, Gunel E, Dogan N. Nonadrenergic, noncholinergic responses of the human colon smooth muscle and the role of K+channels in these responses. Methods Find Exp Clin Pharmacol 2001 Jan-Feb;23(1):13-7.
27. Khattab MM, Gad MZ, Abdallah D. Protective role of nitric oxide in indomethacin- induced gastric ulceration by a mechanism independent of gastric acid secretion. Pharmacol Res 2001 May;43(5):463-7.
28. Thomas S, Ramachandran A, Patra S, et al. Nitric oxide protects the intestine from the damage induced by laparotomy and gut manipulation. J Surg Res 2001 Jul;99(1):25-32.
29. Vallet B. Microthrombosis in sepsis. Minerva Anestesiol 2001 Apr;67(4):298-301.
30. Smith, S. D., et al. Improvement in interstitial cystitis symptoms scores during treatment with oral L-arginine. J Urol. 158(3 Part 1):703-708, 1997.
31. Reckelhoff, J. F., et al. Long-term dietary supplementation with L-arginine prevents age-related reduction in renal function. Am J Physiol. 272(6 Part 2):R1768-R1774, 1997.
32. Field, C. J., et al. Glutamine and arginine: immunonutrients for improved health. Med Sci Sports Exerc. 32:(Suppl) S377-88, 2000.
33. Reynolds, J., et al. Immunologic effects of arginine supplementation in tumor-bearing and non-tumor-bearing hosts. Annals of Surgery. 211:202-209, 19.
34. Cha-Chung, Y. Arrest of mammary tumor growth by l-arginine. Biochemical and Biophysical Research Communications. 95:1306-1313, 1980.
35. Weisburger, J. Prevention by arginine glutamate of the carcinogenicity of acetamide in rats. Toxicology and Applied Pharmacology. 14:163-175, 1969.
36. Rettura, G., et al. Supplemental arginine increases thymic cellularity in normal and murine sarcoma virus-inoculated mice and increases the resistance to murine sarcoma virus tumour. J Par Ent Nutr. 3:409-416, 1979.
37. Heys SD, et al. Dietary supplementation with L-arginine: Modulation of tumor infiltrating lymphocytes in patients with colo-rectal cancer. Br J Surg 1997 Feb;84(2):238-41.
38. Kirk, S. J., et al. Arginine stimulates wound healing and immune function in elderly human beings. Surgery. 114(2):155-159, 1993.
This is third party information. This is for informational purposes only and is not intended to be used for marketing purposes.
39. Blechman, S., et al. L-arginine boosts the immune system. Muscular Development. 38(10):72, 2001.
40. Barbul, A., et al. Arginine stimulates lymphocyte immune response in healthy human beings. Surgery. 90:224-251, 1981.
41. Ochoa, J. B., et al. Effects of L-arginine on the proliferation of T lymphocyte subpopulations. J Parenteral Enteral Nutr. 25:23-29, 2001.
42. Moriguchi, S., et al. Functional changes in human lymphocytes and monocytes after in vitro incubation with arginine. Nutrition Research. 7:719-729, 1987.
43. Dean, W. The neuroendocrine theory of aging part IV: the immune homeostat. Vitamin Research News. October 1999.
44. Efron, D. T., et al. Modulation of inflammation and immunity by arginine supplements. Curr Opin Clin Nutr Metab Care. 1:531-538, 1998.
45. Wilmore, D. W. The effect of glutamine supplementation in patients following elective surgery and accidental injury. Journal of Nutrition. 131(9 Supplement):2543S-2549S, 2001.
46. Morric CR, Kuypers FA, et al. Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome. J Ped Hemat/Onc 2000 Nov-Dec;22(6):515-20.
47. Braverman, Eric R. The Healing Nutrients Within. Keats Publishing, New Canaan, Connecticut, USA. 1997:221.
48. Wascher, T. C., et al. Vascular effects of L-arginine: Anything beyond a substrate for NO synthase? Biochem Biophys Res Com. 234:35-38, 1997.
49. Rossitch E, Jr., et al. L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits. Journal of Clinical Investigation. 87(4):1295-1299, 1991.
50. Ryzenhov, V. E., et al. Action of arginine on the lipid and lipoprotein content in blood serum of animals. Voprosy Meditsinskoi Khimi. 30(6):76-80, 1984.
51. Radner, W., et al. L-arginine reduces kidney collagen accumulation and N-epsilon-(carboxymethyl)lysine in the aging NMRI-mouse. J Gerontol. 49(2):M44-M46, 1994.
52. Piatti, P. M., et al. Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care. 24(5):875-880, 2001.
53. Wascher, T. C., et al. Effects of low-dose L-arginine on insulin mediated vasodilation and insulin sensitivity. Eur J Clin Invest. 27:690-695, 1997.
54. Giugliana D, et al. Vascular effects of acute hyperglycemia are reversed by L-arginine. Circulation 1997; 95(7):1783-90.
55. Mohan IK, Cas UN. Effects of L-arginine-nitric oxide system on chemical induced diabetes mellitus. Free Radic Biol Med 1998 Nov 1;25(7):757-65.
56. Arginine improves blood flow and exercise capacity. Life Enhancement. February 2002:23-26.
57. Beall, C. M., et al. Pulmonary nitric oxide in mountain dwellers. Nature. 414(6862):411-412, 2001.
58. De Gouw HW, Verbruggen MB, Twiss IM, Sterk PJ. Effect of oral L-arginine on airway hyper-responsiveness to histamine in asthma. Thorax 1999 Nov;54(11):1033-5.
59. Moss, Ralph W. Cancer Therapy: The Independent Consumer’s Guide to Non-Toxic Treatment & Prevention. Equinox Press, Brooklyn, New York, USA. 1992:285-287.
60. Khedara A, Kawai Y Kayashita J Kato N. Feeding rats the nitric oxide synthase inhibitor, L-N(omega) nitroarginine, elevates serum triglycerides and cholesterol and lowers hepatic fatty acid oxidation. J Nutr 1996 Oct;126(10):2563-7.
This is third party information. This is for informational purposes only and is not intended to be used for marketing purposes.
61. Gianotti L, Macario M, Lanfranco F, et al. Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab 2000 Oct;85(10):3604-8.
62. Ashish, D., et al. Nitric oxide modulates fracture healing. Journal of Bone and Mineral Research. 15(2):342-351, 2000.
63. Barbul, A. Arginine: biochemistry, physiology, and therapeutic implications. J Parent Ent Nutr. 10:227-238, 1986.
64. Braverman, Eric R. The Healing Nutrients Within. Keats Publishing, New Canaan, Connecticut, USA. 1997:220.
65. Visser, J. J., et al. Arginine supplementation in the prevention and treatment of osteoporosis. Medical Hypotheses. 43(5):339-342, 1994.
66. Arginine improves blood flow and exercise capacity. Life Enhancement. February 2002:23-26.
67. Stevens BR, Godfrey MD, Kaminski TW, Braith RW. High intensity dynamic human muscle performance enhanced by a metabolic intervention. Med Sci Sports Exerc 2000 Dec;32(12):2102-2104.
68. Bradley SJ, Kingwell BA, McConell GK. Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans. Diabetes 1999 Sep; 48(9):1815-21.
69. Tarkowski E, et al. Intrathecal release of nitric oxide in Alzheimer’s disease and vascular dementia. Dement Geriatr Cogn Disord 2000 Nov- Dec;11(6):322-6.
70. Cestaro, B. Effects of arginine, S-adenosylmethionine and polyamines on nerve regeneration. Acta Neurol Scand Suppl. 154:32-41, 1994.
71. Pautler EL. The possible role and treatment of deficient microcirculation regulation in age-associated memory impairment. Med Hypotheses 1994 Jun;42(6):363-6.
72. Pandhi P, Balakrishnan S. Cognitive dysfunction induced by phenytoin and valproate in rats: effect of nitric oxide. Indian J Physiol Pharmacol 1999 Jul; 43(3):378-82.
73. di Luigi L, Guidetti L, Pigozzi F, et al. Acute amino acid supplementation enhances pituitary responsiveness in athletes. Med Sci Sports Exerc 1999 Dec;31(12):1748-54.
74. Chen, J., et al. Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double blind, randomized, placebo-controlled study. British Journal of Urology. 83:269-273, 1999.
75. Papp, G., et al. [The role of arginine and arginase activity in fertility]. Andrologia. 11:37-41, 1979.
76. Women and sex drive. Life Enhancement. December 1999.
77. Block, W. Sexual enhancement available to women too. Viagra duality: better to NO? Life Enhancement. July 1998:15-18.
78. Chen J, Wollman Y, Chernichovsky T, et al. Effect of high dose nitric oxide donor L-arginine in men with organic erectile dysfunction. BJU Int 1999 Feb;83(3):269-73.
79. Keller, D. W., et al. L-arginine stimulation of human sperm motility in vitro. Biol Reprod. 13:154-157, 1975.
80. Aikawa K, Yokota T, et al. Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: the change with aging. Prostate 2001 Jun 15;48(1):40-6.
81. Revolutionary treatments for baldness: The hair re-growth formulas of Peter Proctor, M. D., Ph.D. Life Extension. 3(3):2-8, 1997.
This is third party information. This is for informational purposes only and is not intended to be used for marketing purposes.
82. Block, W. The science of keeping your skin young. Life Enhancement. January 1998:15-18.
83. Kirk, S. J., et al. Arginine stimulates wound healing and immune function in elderly human beings. Surgery. 114(2):155-160, 1993.
84. Barbul, A., et al. Arginine: Supplemental arginine, wound healing, and thymus: Arginine-pituitary interaction. Surgical Forum. 29:93, 1978.
85. Yu, Y., et al. Kinetics of plasma arginine and leucine in pediatric burn patients. American Journal of Clinical Nutrition. 64(1):60-66, 1996.
86. Tepaske, R., et al. Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial. Lancet. 358:696-701, 2001.
87. Braga M, Gianotti L Raedelli G, et al. Perioperative immunonutrition in patients undergoing cancer surgery: results of a randomized double-blind phase 3 trial. Arch Surg 1999 Apr;134(4):428-33.
88. Freedman RR, Girgis R, Mayers MD. Acute effect if nitric oxide on Raynaud’s phenomenon in scleroderma. Lancet 1999 Aug 28:354;739.
89. Fideieff HL,et al. Reproducibility and safety of the arginine test in normal adults. Medicina (B Aires) 1999; 59(3):249-53.
About the Author:
Dr. Harry Elwardt is a Naturopathic Doctor, Master Herbalist, Certified Nutritional Counselor and a Ph.D. in Health & Nutrition. Dr. Elwardt has been working in the alternative medicine field for 10 years and is passionate about helping people through naturopathic therapies. Dr. Elwardt is author of the book “Let’s STOP The #1 Killer Of Americans TODAY,” a natural approach to preventing and reversing heart disease. Dr. Elwardt also serves on the Medical Advisory Board for Nutrition & Kids, Life Mission International, The Bahamas Health Institute, and Ark World International.
1. Radner, W., et al. L-arginine reduces kidney collagen accumulation and N-epsilon-(carboxymethyl)lysine in the aging NMRI-mouse. J Gerontol. 49(2):M44-M46, 1994.
2. Gianotti L, Macario M, Lanfranco F, et al. Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab 2000 Oct;85(10):3604-8.
3. Ceremuzynski, L., et al. Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris. Am J Cardiol. 80:331-333, 1997.
4. Adams, R. R., et al. Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis. 129(2):261-269, 1997.
5. Adams, M. R., et al. Cigarette smoking is associated with increased human monocyte adhesion to endothelial cells: reversibility with oral L-arginine but not vitamin C. Journal of the American College of Cardiology. 29(3):491-497, 1997.
6. Huk, I., et al. L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemica/reperfusion injury in skeletal muscle. Circulation. 96:667-675, 1997.
7. Drexler H, et al. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. The Lancet. 338:1546-50, 1991.
8. Huk, I., et al. L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemica/reperfusion injury in skeletal muscle. Circulation. 96:667-675, 1997.
9. Koifman, B., et al. Improvement of cardiac performance by intravenous infusion of l-arginine in patients with moderate congestive heart failure. Journal of the American College of Cardiology. 26(5):1251-6, 1995.
10. Quyyumi AA. Does acute improvement of endothelial dysfunction in coronary arterydisease improve myocardial ischemia? J Am Coll Cardiol 1998 Oct;32(4):904-11.
11. Khosh, F. Natural approach to hypertension. Alternative Medicine Review. 6(6), 2001.
12. Sisic D, Francishetti A, Frolich ED. Prolonged L-arginine on cardiovascular mass and myocardial hemodynamics and collagen in aged spontaneously hypertensive and normal rats. Hypertension 1999 Jan;33(1 Pt 2):451-5.
13. Nakaki T, et al. L-arginine induced hypotension. Lancet 1990Oct 20; 336(8721):1016-7.
14. Nagaya, N., et al. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Resp Crit Care Med. 163(4):887-891, 2001.
15. Roberts, A. J., et al. Nutraceuticals: The Complete Encyclopedia of Supplements, Herbs, Vitamins and Healing Foods. Berkely Publishing Group. New York, USA. 2001:319.
16. Maxwell AJ, Anderson B Zapien MP, Cooke JP. Endothelial dysfunction in hypercholesterolemia is reversed by: nutritional product designed to enhance nitric oxide activity. Cardiovasc Drugs Ther 2000 Jun;14(3):309-16.
17. Maxwell AJ, Anderson BE Cooke JP. Nutritional therapy for peripheral artery disease. Vasc Med 2000;5(1):11-19.
18. Wallace AW, Ratcliffe MB, Galindez D, Kong JS. L-arginine infusion dilates coronary vasculature in patients undergoing coronary bypass surgery Aenesthesiology 1999 Jun;90(6):1577-8.
This is third party information. This is for informational purposes only and is not intended to be used for marketing purposes.
19. Bode-Boger SM, Boger RH, et al. Differential inhibition of human platelet aggregation and thromboxane A 2 formation by L-arginine in vivo and in vitro. Arch Pharmacol 1998; 357:143-150.
20. Le Yorneau T, Van Belle E, Corseaux D, et al . Role of nitric oxide in re-stenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit. J Am CollCardiol 1999 Mar;33(3):876-82.
21. Suematsu Y, Ohtsuka T, et al. L-Arginine given after ischemic preconditioning can enhance cardioprotection in isolated rat hearts. Eur J Cardiothorac Surg 2001, Jun;19(6):873-9.
22. Hambrecht R, et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol 2000 Mar 1; 35(3):706-13.
23. Bode-Boger SM, Boger RH,et al. L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study. Circulation 1996 Jan 1; 93(1):85-90.
24. Miller, A. L. The pathogenesis, clinical implications, and treatment of intestinal hyperpermeability. Alternative Medicine Review. 2(5):330-345, 1997.
25. Segala, M. (editor). Disease Prevention and Treatment 3rd Edition. Life Extension Media. Florida, USA. 2000:202.
26. Sahin AS, Atalik KE, Gunel E, Dogan N. Nonadrenergic, noncholinergic responses of the human colon smooth muscle and the role of K+channels in these responses. Methods Find Exp Clin Pharmacol 2001 Jan-Feb;23(1):13-7.
27. Khattab MM, Gad MZ, Abdallah D. Protective role of nitric oxide in indomethacin- induced gastric ulceration by a mechanism independent of gastric acid secretion. Pharmacol Res 2001 May;43(5):463-7.
28. Thomas S, Ramachandran A, Patra S, et al. Nitric oxide protects the intestine from the damage induced by laparotomy and gut manipulation. J Surg Res 2001 Jul;99(1):25-32.
29. Vallet B. Microthrombosis in sepsis. Minerva Anestesiol 2001 Apr;67(4):298-301.
30. Smith, S. D., et al. Improvement in interstitial cystitis symptoms scores during treatment with oral L-arginine. J Urol. 158(3 Part 1):703-708, 1997.
31. Reckelhoff, J. F., et al. Long-term dietary supplementation with L-arginine prevents age-related reduction in renal function. Am J Physiol. 272(6 Part 2):R1768-R1774, 1997.
32. Field, C. J., et al. Glutamine and arginine: immunonutrients for improved health. Med Sci Sports Exerc. 32:(Suppl) S377-88, 2000.
33. Reynolds, J., et al. Immunologic effects of arginine supplementation in tumor-bearing and non-tumor-bearing hosts. Annals of Surgery. 211:202-209, 19.
34. Cha-Chung, Y. Arrest of mammary tumor growth by l-arginine. Biochemical and Biophysical Research Communications. 95:1306-1313, 1980.
35. Weisburger, J. Prevention by arginine glutamate of the carcinogenicity of acetamide in rats. Toxicology and Applied Pharmacology. 14:163-175, 1969.
36. Rettura, G., et al. Supplemental arginine increases thymic cellularity in normal and murine sarcoma virus-inoculated mice and increases the resistance to murine sarcoma virus tumour. J Par Ent Nutr. 3:409-416, 1979.
37. Heys SD, et al. Dietary supplementation with L-arginine: Modulation of tumor infiltrating lymphocytes in patients with colo-rectal cancer. Br J Surg 1997 Feb;84(2):238-41.
38. Kirk, S. J., et al. Arginine stimulates wound healing and immune function in elderly human beings. Surgery. 114(2):155-159, 1993.
This is third party information. This is for informational purposes only and is not intended to be used for marketing purposes.
39. Blechman, S., et al. L-arginine boosts the immune system. Muscular Development. 38(10):72, 2001.
40. Barbul, A., et al. Arginine stimulates lymphocyte immune response in healthy human beings. Surgery. 90:224-251, 1981.
41. Ochoa, J. B., et al. Effects of L-arginine on the proliferation of T lymphocyte subpopulations. J Parenteral Enteral Nutr. 25:23-29, 2001.
42. Moriguchi, S., et al. Functional changes in human lymphocytes and monocytes after in vitro incubation with arginine. Nutrition Research. 7:719-729, 1987.
43. Dean, W. The neuroendocrine theory of aging part IV: the immune homeostat. Vitamin Research News. October 1999.
44. Efron, D. T., et al. Modulation of inflammation and immunity by arginine supplements. Curr Opin Clin Nutr Metab Care. 1:531-538, 1998.
45. Wilmore, D. W. The effect of glutamine supplementation in patients following elective surgery and accidental injury. Journal of Nutrition. 131(9 Supplement):2543S-2549S, 2001.
46. Morric CR, Kuypers FA, et al. Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome. J Ped Hemat/Onc 2000 Nov-Dec;22(6):515-20.
47. Braverman, Eric R. The Healing Nutrients Within. Keats Publishing, New Canaan, Connecticut, USA. 1997:221.
48. Wascher, T. C., et al. Vascular effects of L-arginine: Anything beyond a substrate for NO synthase? Biochem Biophys Res Com. 234:35-38, 1997.
49. Rossitch E, Jr., et al. L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits. Journal of Clinical Investigation. 87(4):1295-1299, 1991.
50. Ryzenhov, V. E., et al. Action of arginine on the lipid and lipoprotein content in blood serum of animals. Voprosy Meditsinskoi Khimi. 30(6):76-80, 1984.
51. Radner, W., et al. L-arginine reduces kidney collagen accumulation and N-epsilon-(carboxymethyl)lysine in the aging NMRI-mouse. J Gerontol. 49(2):M44-M46, 1994.
52. Piatti, P. M., et al. Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care. 24(5):875-880, 2001.
53. Wascher, T. C., et al. Effects of low-dose L-arginine on insulin mediated vasodilation and insulin sensitivity. Eur J Clin Invest. 27:690-695, 1997.
54. Giugliana D, et al. Vascular effects of acute hyperglycemia are reversed by L-arginine. Circulation 1997; 95(7):1783-90.
55. Mohan IK, Cas UN. Effects of L-arginine-nitric oxide system on chemical induced diabetes mellitus. Free Radic Biol Med 1998 Nov 1;25(7):757-65.
56. Arginine improves blood flow and exercise capacity. Life Enhancement. February 2002:23-26.
57. Beall, C. M., et al. Pulmonary nitric oxide in mountain dwellers. Nature. 414(6862):411-412, 2001.
58. De Gouw HW, Verbruggen MB, Twiss IM, Sterk PJ. Effect of oral L-arginine on airway hyper-responsiveness to histamine in asthma. Thorax 1999 Nov;54(11):1033-5.
59. Moss, Ralph W. Cancer Therapy: The Independent Consumer’s Guide to Non-Toxic Treatment & Prevention. Equinox Press, Brooklyn, New York, USA. 1992:285-287.
60. Khedara A, Kawai Y Kayashita J Kato N. Feeding rats the nitric oxide synthase inhibitor, L-N(omega) nitroarginine, elevates serum triglycerides and cholesterol and lowers hepatic fatty acid oxidation. J Nutr 1996 Oct;126(10):2563-7.
This is third party information. This is for informational purposes only and is not intended to be used for marketing purposes.
61. Gianotti L, Macario M, Lanfranco F, et al. Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab 2000 Oct;85(10):3604-8.
62. Ashish, D., et al. Nitric oxide modulates fracture healing. Journal of Bone and Mineral Research. 15(2):342-351, 2000.
63. Barbul, A. Arginine: biochemistry, physiology, and therapeutic implications. J Parent Ent Nutr. 10:227-238, 1986.
64. Braverman, Eric R. The Healing Nutrients Within. Keats Publishing, New Canaan, Connecticut, USA. 1997:220.
65. Visser, J. J., et al. Arginine supplementation in the prevention and treatment of osteoporosis. Medical Hypotheses. 43(5):339-342, 1994.
66. Arginine improves blood flow and exercise capacity. Life Enhancement. February 2002:23-26.
67. Stevens BR, Godfrey MD, Kaminski TW, Braith RW. High intensity dynamic human muscle performance enhanced by a metabolic intervention. Med Sci Sports Exerc 2000 Dec;32(12):2102-2104.
68. Bradley SJ, Kingwell BA, McConell GK. Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans. Diabetes 1999 Sep; 48(9):1815-21.
69. Tarkowski E, et al. Intrathecal release of nitric oxide in Alzheimer’s disease and vascular dementia. Dement Geriatr Cogn Disord 2000 Nov- Dec;11(6):322-6.
70. Cestaro, B. Effects of arginine, S-adenosylmethionine and polyamines on nerve regeneration. Acta Neurol Scand Suppl. 154:32-41, 1994.
71. Pautler EL. The possible role and treatment of deficient microcirculation regulation in age-associated memory impairment. Med Hypotheses 1994 Jun;42(6):363-6.
72. Pandhi P, Balakrishnan S. Cognitive dysfunction induced by phenytoin and valproate in rats: effect of nitric oxide. Indian J Physiol Pharmacol 1999 Jul; 43(3):378-82.
73. di Luigi L, Guidetti L, Pigozzi F, et al. Acute amino acid supplementation enhances pituitary responsiveness in athletes. Med Sci Sports Exerc 1999 Dec;31(12):1748-54.
74. Chen, J., et al. Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double blind, randomized, placebo-controlled study. British Journal of Urology. 83:269-273, 1999.
75. Papp, G., et al. [The role of arginine and arginase activity in fertility]. Andrologia. 11:37-41, 1979.
76. Women and sex drive. Life Enhancement. December 1999.
77. Block, W. Sexual enhancement available to women too. Viagra duality: better to NO? Life Enhancement. July 1998:15-18.
78. Chen J, Wollman Y, Chernichovsky T, et al. Effect of high dose nitric oxide donor L-arginine in men with organic erectile dysfunction. BJU Int 1999 Feb;83(3):269-73.
79. Keller, D. W., et al. L-arginine stimulation of human sperm motility in vitro. Biol Reprod. 13:154-157, 1975.
80. Aikawa K, Yokota T, et al. Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: the change with aging. Prostate 2001 Jun 15;48(1):40-6.
81. Revolutionary treatments for baldness: The hair re-growth formulas of Peter Proctor, M. D., Ph.D. Life Extension. 3(3):2-8, 1997.
This is third party information. This is for informational purposes only and is not intended to be used for marketing purposes.
82. Block, W. The science of keeping your skin young. Life Enhancement. January 1998:15-18.
83. Kirk, S. J., et al. Arginine stimulates wound healing and immune function in elderly human beings. Surgery. 114(2):155-160, 1993.
84. Barbul, A., et al. Arginine: Supplemental arginine, wound healing, and thymus: Arginine-pituitary interaction. Surgical Forum. 29:93, 1978.
85. Yu, Y., et al. Kinetics of plasma arginine and leucine in pediatric burn patients. American Journal of Clinical Nutrition. 64(1):60-66, 1996.
86. Tepaske, R., et al. Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial. Lancet. 358:696-701, 2001.
87. Braga M, Gianotti L Raedelli G, et al. Perioperative immunonutrition in patients undergoing cancer surgery: results of a randomized double-blind phase 3 trial. Arch Surg 1999 Apr;134(4):428-33.
88. Freedman RR, Girgis R, Mayers MD. Acute effect if nitric oxide on Raynaud’s phenomenon in scleroderma. Lancet 1999 Aug 28:354;739.
89. Fideieff HL,et al. Reproducibility and safety of the arginine test in normal adults. Medicina (B Aires) 1999; 59(3):249-53.
About the Author:
Dr. Harry Elwardt is a Naturopathic Doctor, Master Herbalist, Certified Nutritional Counselor and a Ph.D. in Health & Nutrition. Dr. Elwardt has been working in the alternative medicine field for 10 years and is passionate about helping people through naturopathic therapies. Dr. Elwardt is author of the book “Let’s STOP The #1 Killer Of Americans TODAY,” a natural approach to preventing and reversing heart disease. Dr. Elwardt also serves on the Medical Advisory Board for Nutrition & Kids, Life Mission International, The Bahamas Health Institute, and Ark World International.
1. Radner, W., et al. L-arginine reduces kidney collagen accumulation and N-epsilon-(carboxymethyl)lysine in the aging NMRI-mouse. J Gerontol. 49(2):M44-M46, 1994.
2. Gianotti L, Macario M, Lanfranco F, et al. Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab 2000 Oct;85(10):3604-8.
3. Ceremuzynski, L., et al. Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris. Am J Cardiol. 80:331-333, 1997.
4. Adams, R. R., et al. Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis. 129(2):261-269, 1997.
5. Adams, M. R., et al. Cigarette smoking is associated with increased human monocyte adhesion to endothelial cells: reversibility with oral L-arginine but not vitamin C. Journal of the American College of Cardiology. 29(3):491-497, 1997.
6. Huk, I., et al. L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemica/reperfusion injury in skeletal muscle. Circulation. 96:667-675, 1997.
7. Drexler H, et al. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. The Lancet. 338:1546-50, 1991.
8. Huk, I., et al. L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemica/reperfusion injury in skeletal muscle. Circulation. 96:667-675, 1997.
9. Koifman, B., et al. Improvement of cardiac performance by intravenous infusion of l-arginine in patients with moderate congestive heart failure. Journal of the American College of Cardiology. 26(5):1251-6, 1995.
10. Quyyumi AA. Does acute improvement of endothelial dysfunction in coronary arterydisease improve myocardial ischemia? J Am Coll Cardiol 1998 Oct;32(4):904-11.
11. Khosh, F. Natural approach to hypertension. Alternative Medicine Review. 6(6), 2001.
12. Sisic D, Francishetti A, Frolich ED. Prolonged L-arginine on cardiovascular mass and myocardial hemodynamics and collagen in aged spontaneously hypertensive and normal rats. Hypertension 1999 Jan;33(1 Pt 2):451-5.
13. Nakaki T, et al. L-arginine induced hypotension. Lancet 1990Oct 20; 336(8721):1016-7.
14. Nagaya, N., et al. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Resp Crit Care Med. 163(4):887-891, 2001.
15. Roberts, A. J., et al. Nutraceuticals: The Complete Encyclopedia of Supplements, Herbs, Vitamins and Healing Foods. Berkely Publishing Group. New York, USA. 2001:319.
16. Maxwell AJ, Anderson B Zapien MP, Cooke JP. Endothelial dysfunction in hypercholesterolemia is reversed by: nutritional product designed to enhance nitric oxide activity. Cardiovasc Drugs Ther 2000 Jun;14(3):309-16.
17. Maxwell AJ, Anderson BE Cooke JP. Nutritional therapy for peripheral artery disease. Vasc Med 2000;5(1):11-19.
18. Wallace AW, Ratcliffe MB, Galindez D, Kong JS. L-arginine infusion dilates coronary vasculature in patients undergoing coronary bypass surgery Aenesthesiology 1999 Jun;90(6):1577-8.
This is third party information. This is for informational purposes only and is not intended to be used for marketing purposes.
19. Bode-Boger SM, Boger RH, et al. Differential inhibition of human platelet aggregation and thromboxane A 2 formation by L-arginine in vivo and in vitro. Arch Pharmacol 1998; 357:143-150.
20. Le Yorneau T, Van Belle E, Corseaux D, et al . Role of nitric oxide in re-stenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit. J Am CollCardiol 1999 Mar;33(3):876-82.
21. Suematsu Y, Ohtsuka T, et al. L-Arginine given after ischemic preconditioning can enhance cardioprotection in isolated rat hearts. Eur J Cardiothorac Surg 2001, Jun;19(6):873-9.
22. Hambrecht R, et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol 2000 Mar 1; 35(3):706-13.
23. Bode-Boger SM, Boger RH,et al. L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study. Circulation 1996 Jan 1; 93(1):85-90.
24. Miller, A. L. The pathogenesis, clinical implications, and treatment of intestinal hyperpermeability. Alternative Medicine Review. 2(5):330-345, 1997.
25. Segala, M. (editor). Disease Prevention and Treatment 3rd Edition. Life Extension Media. Florida, USA. 2000:202.
26. Sahin AS, Atalik KE, Gunel E, Dogan N. Nonadrenergic, noncholinergic responses of the human colon smooth muscle and the role of K+channels in these responses. Methods Find Exp Clin Pharmacol 2001 Jan-Feb;23(1):13-7.
27. Khattab MM, Gad MZ, Abdallah D. Protective role of nitric oxide in indomethacin- induced gastric ulceration by a mechanism independent of gastric acid secretion. Pharmacol Res 2001 May;43(5):463-7.
28. Thomas S, Ramachandran A, Patra S, et al. Nitric oxide protects the intestine from the damage induced by laparotomy and gut manipulation. J Surg Res 2001 Jul;99(1):25-32.
29. Vallet B. Microthrombosis in sepsis. Minerva Anestesiol 2001 Apr;67(4):298-301.
30. Smith, S. D., et al. Improvement in interstitial cystitis symptoms scores during treatment with oral L-arginine. J Urol. 158(3 Part 1):703-708, 1997.
31. Reckelhoff, J. F., et al. Long-term dietary supplementation with L-arginine prevents age-related reduction in renal function. Am J Physiol. 272(6 Part 2):R1768-R1774, 1997.
32. Field, C. J., et al. Glutamine and arginine: immunonutrients for improved health. Med Sci Sports Exerc. 32:(Suppl) S377-88, 2000.
33. Reynolds, J., et al. Immunologic effects of arginine supplementation in tumor-bearing and non-tumor-bearing hosts. Annals of Surgery. 211:202-209, 19.
34. Cha-Chung, Y. Arrest of mammary tumor growth by l-arginine. Biochemical and Biophysical Research Communications. 95:1306-1313, 1980.
35. Weisburger, J. Prevention by arginine glutamate of the carcinogenicity of acetamide in rats. Toxicology and Applied Pharmacology. 14:163-175, 1969.
36. Rettura, G., et al. Supplemental arginine increases thymic cellularity in normal and murine sarcoma virus-inoculated mice and increases the resistance to murine sarcoma virus tumour. J Par Ent Nutr. 3:409-416, 1979.
37. Heys SD, et al. Dietary supplementation with L-arginine: Modulation of tumor infiltrating lymphocytes in patients with colo-rectal cancer. Br J Surg 1997 Feb;84(2):238-41.
38. Kirk, S. J., et al. Arginine stimulates wound healing and immune function in elderly human beings. Surgery. 114(2):155-159, 1993.
This is third party information. This is for informational purposes only and is not intended to be used for marketing purposes.
39. Blechman, S., et al. L-arginine boosts the immune system. Muscular Development. 38(10):72, 2001.
40. Barbul, A., et al. Arginine stimulates lymphocyte immune response in healthy human beings. Surgery. 90:224-251, 1981.
41. Ochoa, J. B., et al. Effects of L-arginine on the proliferation of T lymphocyte subpopulations. J Parenteral Enteral Nutr. 25:23-29, 2001.
42. Moriguchi, S., et al. Functional changes in human lymphocytes and monocytes after in vitro incubation with arginine. Nutrition Research. 7:719-729, 1987.
43. Dean, W. The neuroendocrine theory of aging part IV: the immune homeostat. Vitamin Research News. October 1999.
44. Efron, D. T., et al. Modulation of inflammation and immunity by arginine supplements. Curr Opin Clin Nutr Metab Care. 1:531-538, 1998.
45. Wilmore, D. W. The effect of glutamine supplementation in patients following elective surgery and accidental injury. Journal of Nutrition. 131(9 Supplement):2543S-2549S, 2001.
46. Morric CR, Kuypers FA, et al. Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome. J Ped Hemat/Onc 2000 Nov-Dec;22(6):515-20.
47. Braverman, Eric R. The Healing Nutrients Within. Keats Publishing, New Canaan, Connecticut, USA. 1997:221.
48. Wascher, T. C., et al. Vascular effects of L-arginine: Anything beyond a substrate for NO synthase? Biochem Biophys Res Com. 234:35-38, 1997.
49. Rossitch E, Jr., et al. L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits. Journal of Clinical Investigation. 87(4):1295-1299, 1991.
50. Ryzenhov, V. E., et al. Action of arginine on the lipid and lipoprotein content in blood serum of animals. Voprosy Meditsinskoi Khimi. 30(6):76-80, 1984.
51. Radner, W., et al. L-arginine reduces kidney collagen accumulation and N-epsilon-(carboxymethyl)lysine in the aging NMRI-mouse. J Gerontol. 49(2):M44-M46, 1994.
52. Piatti, P. M., et al. Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care. 24(5):875-880, 2001.
53. Wascher, T. C., et al. Effects of low-dose L-arginine on insulin mediated vasodilation and insulin sensitivity. Eur J Clin Invest. 27:690-695, 1997.
54. Giugliana D, et al. Vascular effects of acute hyperglycemia are reversed by L-arginine. Circulation 1997; 95(7):1783-90.
55. Mohan IK, Cas UN. Effects of L-arginine-nitric oxide system on chemical induced diabetes mellitus. Free Radic Biol Med 1998 Nov 1;25(7):757-65.
56. Arginine improves blood flow and exercise capacity. Life Enhancement. February 2002:23-26.
57. Beall, C. M., et al. Pulmonary nitric oxide in mountain dwellers. Nature. 414(6862):411-412, 2001.
58. De Gouw HW, Verbruggen MB, Twiss IM, Sterk PJ. Effect of oral L-arginine on airway hyper-responsiveness to histamine in asthma. Thorax 1999 Nov;54(11):1033-5.
59. Moss, Ralph W. Cancer Therapy: The Independent Consumer’s Guide to Non-Toxic Treatment & Prevention. Equinox Press, Brooklyn, New York, USA. 1992:285-287.
60. Khedara A, Kawai Y Kayashita J Kato N. Feeding rats the nitric oxide synthase inhibitor, L-N(omega) nitroarginine, elevates serum triglycerides and cholesterol and lowers hepatic fatty acid oxidation. J Nutr 1996 Oct;126(10):2563-7.
This is third party information. This is for informational purposes only and is not intended to be used for marketing purposes.
61. Gianotti L, Macario M, Lanfranco F, et al. Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab 2000 Oct;85(10):3604-8.
62. Ashish, D., et al. Nitric oxide modulates fracture healing. Journal of Bone and Mineral Research. 15(2):342-351, 2000.
63. Barbul, A. Arginine: biochemistry, physiology, and therapeutic implications. J Parent Ent Nutr. 10:227-238, 1986.
64. Braverman, Eric R. The Healing Nutrients Within. Keats Publishing, New Canaan, Connecticut, USA. 1997:220.
65. Visser, J. J., et al. Arginine supplementation in the prevention and treatment of osteoporosis. Medical Hypotheses. 43(5):339-342, 1994.
66. Arginine improves blood flow and exercise capacity. Life Enhancement. February 2002:23-26.
67. Stevens BR, Godfrey MD, Kaminski TW, Braith RW. High intensity dynamic human muscle performance enhanced by a metabolic intervention. Med Sci Sports Exerc 2000 Dec;32(12):2102-2104.
68. Bradley SJ, Kingwell BA, McConell GK. Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans. Diabetes 1999 Sep; 48(9):1815-21.
69. Tarkowski E, et al. Intrathecal release of nitric oxide in Alzheimer’s disease and vascular dementia. Dement Geriatr Cogn Disord 2000 Nov- Dec;11(6):322-6.
70. Cestaro, B. Effects of arginine, S-adenosylmethionine and polyamines on nerve regeneration. Acta Neurol Scand Suppl. 154:32-41, 1994.
71. Pautler EL. The possible role and treatment of deficient microcirculation regulation in age-associated memory impairment. Med Hypotheses 1994 Jun;42(6):363-6.
72. Pandhi P, Balakrishnan S. Cognitive dysfunction induced by phenytoin and valproate in rats: effect of nitric oxide. Indian J Physiol Pharmacol 1999 Jul; 43(3):378-82.
73. di Luigi L, Guidetti L, Pigozzi F, et al. Acute amino acid supplementation enhances pituitary responsiveness in athletes. Med Sci Sports Exerc 1999 Dec;31(12):1748-54.
74. Chen, J., et al. Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double blind, randomized, placebo-controlled study. British Journal of Urology. 83:269-273, 1999.
75. Papp, G., et al. [The role of arginine and arginase activity in fertility]. Andrologia. 11:37-41, 1979.
76. Women and sex drive. Life Enhancement. December 1999.
77. Block, W. Sexual enhancement available to women too. Viagra duality: better to NO? Life Enhancement. July 1998:15-18.
78. Chen J, Wollman Y, Chernichovsky T, et al. Effect of high dose nitric oxide donor L-arginine in men with organic erectile dysfunction. BJU Int 1999 Feb;83(3):269-73.
79. Keller, D. W., et al. L-arginine stimulation of human sperm motility in vitro. Biol Reprod. 13:154-157, 1975.
80. Aikawa K, Yokota T, et al. Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: the change with aging. Prostate 2001 Jun 15;48(1):40-6.
81. Revolutionary treatments for baldness: The hair re-growth formulas of Peter Proctor, M. D., Ph.D. Life Extension. 3(3):2-8, 1997.
This is third party information. This is for informational purposes only and is not intended to be used for marketing purposes.
82. Block, W. The science of keeping your skin young. Life Enhancement. January 1998:15-18.
83. Kirk, S. J., et al. Arginine stimulates wound healing and immune function in elderly human beings. Surgery. 114(2):155-160, 1993.
84. Barbul, A., et al. Arginine: Supplemental arginine, wound healing, and thymus: Arginine-pituitary interaction. Surgical Forum. 29:93, 1978.
85. Yu, Y., et al. Kinetics of plasma arginine and leucine in pediatric burn patients. American Journal of Clinical Nutrition. 64(1):60-66, 1996.
86. Tepaske, R., et al. Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial. Lancet. 358:696-701, 2001.
87. Braga M, Gianotti L Raedelli G, et al. Perioperative immunonutrition in patients undergoing cancer surgery: results of a randomized double-blind phase 3 trial. Arch Surg 1999 Apr;134(4):428-33.
88. Freedman RR, Girgis R, Mayers MD. Acute effect if nitric oxide on Raynaud’s phenomenon in scleroderma. Lancet 1999 Aug 28:354;739.
89. Fideieff HL,et al. Reproducibility and safety of the arginine test in normal adults. Medicina (B Aires) 1999; 59(3):249-53.
About the Author:
Dr. Harry Elwardt is a Naturopathic Doctor, Master Herbalist, Certified Nutritional Counselor and a Ph.D. in Health & Nutrition. Dr. Elwardt has been working in the alternative medicine field for 10 years and is passionate about helping people through naturopathic therapies. Dr. Elwardt is author of the book “Let’s STOP The #1 Killer Of Americans TODAY,” a natural approach to preventing and reversing heart disease. Dr. Elwardt also serves on the Medical Advisory Board for Nutrition & Kids, Life Mission International, The Bahamas Health Institute, and Ark World International.
1. Radner, W., et al. L-arginine reduces kidney collagen accumulation and N-epsilon-(carboxymethyl)lysine in the aging NMRI-mouse. J Gerontol. 49(2):M44-M46, 1994.
2. Gianotti L, Macario M, Lanfranco F, et al. Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab 2000 Oct;85(10):3604-8.
3. Ceremuzynski, L., et al. Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris. Am J Cardiol. 80:331-333, 1997.
4. Adams, R. R., et al. Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis. 129(2):261-269, 1997.
5. Adams, M. R., et al. Cigarette smoking is associated with increased human monocyte adhesion to endothelial cells: reversibility with oral L-arginine but not vitamin C. Journal of the American College of Cardiology. 29(3):491-497, 1997.
6. Huk, I., et al. L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemica/reperfusion injury in skeletal muscle. Circulation. 96:667-675, 1997.
7. Drexler H, et al. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. The Lancet. 338:1546-50, 1991.
8. Huk, I., et al. L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemica/reperfusion injury in skeletal muscle. Circulation. 96:667-675, 1997.
9. Koifman, B., et al. Improvement of cardiac performance by intravenous infusion of l-arginine in patients with moderate congestive heart failure. Journal of the American College of Cardiology. 26(5):1251-6, 1995.
10. Quyyumi AA. Does acute improvement of endothelial dysfunction in coronary arterydisease improve myocardial ischemia? J Am Coll Cardiol 1998 Oct;32(4):904-11.
11. Khosh, F. Natural approach to hypertension. Alternative Medicine Review. 6(6), 2001.
12. Sisic D, Francishetti A, Frolich ED. Prolonged L-arginine on cardiovascular mass and myocardial hemodynamics and collagen in aged spontaneously hypertensive and normal rats. Hypertension 1999 Jan;33(1 Pt 2):451-5.
13. Nakaki T, et al. L-arginine induced hypotension. Lancet 1990Oct 20; 336(8721):1016-7.
14. Nagaya, N., et al. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Resp Crit Care Med. 163(4):887-891, 2001.
15. Roberts, A. J., et al. Nutraceuticals: The Complete Encyclopedia of Supplements, Herbs, Vitamins and Healing Foods. Berkely Publishing Group. New York, USA. 2001:319.
16. Maxwell AJ, Anderson B Zapien MP, Cooke JP. Endothelial dysfunction in hypercholesterolemia is reversed by: nutritional product designed to enhance nitric oxide activity. Cardiovasc Drugs Ther 2000 Jun;14(3):309-16.
17. Maxwell AJ, Anderson BE Cooke JP. Nutritional therapy for peripheral artery disease. Vasc Med 2000;5(1):11-19.
18. Wallace AW, Ratcliffe MB, Galindez D, Kong JS. L-arginine infusion dilates coronary vasculature in patients undergoing coronary bypass surgery Aenesthesiology 1999 Jun;90(6):1577-8.
This is third party information. This is for informational purposes only and is not intended to be used for marketing purposes.
19. Bode-Boger SM, Boger RH, et al. Differential inhibition of human platelet aggregation and thromboxane A 2 formation by L-arginine in vivo and in vitro. Arch Pharmacol 1998; 357:143-150.
20. Le Yorneau T, Van Belle E, Corseaux D, et al . Role of nitric oxide in re-stenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit. J Am CollCardiol 1999 Mar;33(3):876-82.
21. Suematsu Y, Ohtsuka T, et al. L-Arginine given after ischemic preconditioning can enhance cardioprotection in isolated rat hearts. Eur J Cardiothorac Surg 2001, Jun;19(6):873-9.
22. Hambrecht R, et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol 2000 Mar 1; 35(3):706-13.
23. Bode-Boger SM, Boger RH,et al. L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study. Circulation 1996 Jan 1; 93(1):85-90.
24. Miller, A. L. The pathogenesis, clinical implications, and treatment of intestinal hyperpermeability. Alternative Medicine Review. 2(5):330-345, 1997.
25. Segala, M. (editor). Disease Prevention and Treatment 3rd Edition. Life Extension Media. Florida, USA. 2000:202.
26. Sahin AS, Atalik KE, Gunel E, Dogan N. Nonadrenergic, noncholinergic responses of the human colon smooth muscle and the role of K+channels in these responses. Methods Find Exp Clin Pharmacol 2001 Jan-Feb;23(1):13-7.
27. Khattab MM, Gad MZ, Abdallah D. Protective role of nitric oxide in indomethacin- induced gastric ulceration by a mechanism independent of gastric acid secretion. Pharmacol Res 2001 May;43(5):463-7.
28. Thomas S, Ramachandran A, Patra S, et al. Nitric oxide protects the intestine from the damage induced by laparotomy and gut manipulation. J Surg Res 2001 Jul;99(1):25-32.
29. Vallet B. Microthrombosis in sepsis. Minerva Anestesiol 2001 Apr;67(4):298-301.
30. Smith, S. D., et al. Improvement in interstitial cystitis symptoms scores during treatment with oral L-arginine. J Urol. 158(3 Part 1):703-708, 1997.
31. Reckelhoff, J. F., et al. Long-term dietary supplementation with L-arginine prevents age-related reduction in renal function. Am J Physiol. 272(6 Part 2):R1768-R1774, 1997.
32. Field, C. J., et al. Glutamine and arginine: immunonutrients for improved health. Med Sci Sports Exerc. 32:(Suppl) S377-88, 2000.
33. Reynolds, J., et al. Immunologic effects of arginine supplementation in tumor-bearing and non-tumor-bearing hosts. Annals of Surgery. 211:202-209, 19.
34. Cha-Chung, Y. Arrest of mammary tumor growth by l-arginine. Biochemical and Biophysical Research Communications. 95:1306-1313, 1980.
35. Weisburger, J. Prevention by arginine glutamate of the carcinogenicity of acetamide in rats. Toxicology and Applied Pharmacology. 14:163-175, 1969.
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About the Author:
Dr. Harry Elwardt is a Naturopathic Doctor, Master Herbalist, Certified Nutritional Counselor and a Ph.D. in Health & Nutrition. Dr. Elwardt has been working in the alternative medicine field for 10 years and is passionate about helping people through naturopathic therapies. Dr. Elwardt is author of the book “Let’s STOP The #1 Killer Of Americans TODAY,” a natural approach to preventing and reversing heart disease. Dr. Elwardt also serves on the Medical Advisory Board for Nutrition & Kids, Life Mission International, The Bahamas Health Institute, and Ark World International.
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